Sifting through teaspoons of clay and sand scraped from the floors of caves, researchers have managed to isolate ancient human DNA without turning up a single bone. Their new technique, described in a study published on Thursday in the journal Science, promises to open new avenues of research into human prehistory and was met with excitement by geneticists and archaeologists.
“It’s a bit like discovering that you can extract gold dust from the air,”said Adam Siepel, a population geneticist at Cold Spring Harbor Laboratory. “An absolutely amazing and exciting paper,” added David Reich, a genetics professor at Harvard who focuses on ancient DNA.
DNA from fossil bonesUntil recently, the only way to study the genes of ancient humans like the Neanderthals and their cousins, the Denisovans, was to recover DNA from fossil bones. But they are scarce and hard to find, which has greatly limited research into where early humans lived and how widely they ranged.
The only Denisovan bones and teeth that scientists have, for example, come from a single cave in Siberia.Looking for these genetic signposts in sediment has become possible only in the last few years, with recent developments in technology, including rapid sequencing of DNA. Although DNA sticks to minerals and decayed plants in soil, scientists did not know whether it would ever be possible to fish out gene fragments that were tens of thousands of years old and buried deep among other genetic debris.
Long wayBits of genes from ancient humans make up just a minute fraction of the DNA floating around in the natural world. But the German scientists, led by Matthias Meyer at the Max Planck Institute for Developmental Biology in Tübingen, have spent years developing methods to find DNA even where it seemed impossibly scarce and degraded. “There’s been a real revolution in technology invented by this lab,” Dr. Reich said. “Matthias is kind of a wizard in pushing the envelope.” Scientists began by retrieving DNA from ancient bones:
- first Neanderthals,
- then Denisovans.